Drug interactions
Brompheniramine + Clonazepam
Severity: Moderate
Brompheniramine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines such as brompheniramine can add to benzodiazepine drowsiness and impair concentration and coordination. Older adults are at greater risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-receptor blockade with central effects and GABA-A potentiation.
What to do
Avoid combining where possible in older adults, or choose a non-sedating antihistamine. Counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Clonazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines such as brompheniramine can add to benzodiazepine drowsiness and impair concentration and coordination. Older adults are at greater risk of confusion and falls.
How serious is the interaction between Brompheniramine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible in older adults, or choose a non-sedating antihistamine. Counsel on avoiding driving and alcohol.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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