Drug interactions
Brompheniramine + Clozapine
Severity: Moderate
Brompheniramine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating, anticholinergic antihistamine. With clozapine, it may increase drowsiness, psychomotor impairment and anticholinergic effects such as constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Clozapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Avoid prolonged use or choose a non-sedating antihistamine. Monitor for sedation and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Clozapine?
MediHelp rates the interaction as moderate. Brompheniramine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating, anticholinergic antihistamine. With clozapine, it may increase drowsiness, psychomotor impairment and anticholinergic effects such as constipation and urinary retention.
How serious is the interaction between Brompheniramine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged use or choose a non-sedating antihistamine. Monitor for sedation and constipation.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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