Drug interactions
Brompheniramine + Codeine
Severity: Moderate
Brompheniramine and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine added to an opioid can increase drowsiness, impair alertness and potentiate respiratory depression.
What this interaction means in plain words
Brompheniramine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and H1-antihistamine effects.
What to do
Monitor sedation, avoid alcohol and driving, and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Codeine?
MediHelp rates the interaction as moderate. Brompheniramine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine added to an opioid can increase drowsiness, impair alertness and potentiate respiratory depression.
How serious is the interaction between Brompheniramine and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, avoid alcohol and driving, and consider a non-sedating antihistamine.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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