Drug interactions
Brompheniramine + Cyclobenzaprine
Severity: Moderate
Brompheniramine and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating antihistamine with anticholinergic properties, so combining it with cyclobenzaprine increases drowsiness and antimuscarinic effects such as dry mouth, urinary retention and confusion.
What this interaction means in plain words
Brompheniramine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Counsel patients to avoid driving and monitor older adults for confusion and urinary retention. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Brompheniramine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating antihistamine with anticholinergic properties, so combining it with cyclobenzaprine increases drowsiness and antimuscarinic effects such as dry mouth, urinary retention and confusion.
How serious is the interaction between Brompheniramine and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and monitor older adults for confusion and urinary retention. Consider a non-sedating antihistamine instead.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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