Drug interactions
Brompheniramine + Cyproheptadine
Severity: Moderate
Brompheniramine and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation antihistamines, so combining them duplicates therapy and increases sedation and anticholinergic effects such as dry mouth, urinary retention and confusion.
What this interaction means in plain words
Brompheniramine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Cyproheptadine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism with additive antimuscarinic and CNS depressant effects.
What to do
Avoid using two first-generation antihistamines together; use a single agent and counsel on drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Cyproheptadine?
MediHelp rates the interaction as moderate. Brompheniramine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation antihistamines, so combining them duplicates therapy and increases sedation and anticholinergic effects such as dry mouth, urinary retention and confusion.
How serious is the interaction between Brompheniramine and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two first-generation antihistamines together; use a single agent and counsel on drowsiness.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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