Drug interactions
Brompheniramine + Diazepam
Severity: Moderate
Brompheniramine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and combining it with diazepam can substantially increase drowsiness and reduce psychomotor performance. Older adults are at greater risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central H1 antagonism and GABA-A potentiation by diazepam.
What to do
Counsel patients to avoid driving and alcohol, and consider a non-sedating antihistamine instead. In older patients avoid the combination where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Diazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and combining it with diazepam can substantially increase drowsiness and reduce psychomotor performance. Older adults are at greater risk of confusion and falls.
How serious is the interaction between Brompheniramine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, and consider a non-sedating antihistamine instead. In older patients avoid the combination where possible.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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