Drug interactions
Brompheniramine + Dimenhydrinate
Severity: Moderate
Brompheniramine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate releases diphenhydramine, a sedating antihistamine, so combining it with brompheniramine duplicates therapy. This increases drowsiness, impaired coordination and anticholinergic adverse effects.
What this interaction means in plain words
Brompheniramine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and anticholinergic activity.
What to do
Avoid taking both and choose one agent. Warn the patient against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Dimenhydrinate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brompheniramine
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Brompheniramine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Brompheniramine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate releases diphenhydramine, a sedating antihistamine, so combining it with brompheniramine duplicates therapy. This increases drowsiness, impaired coordination and anticholinergic adverse effects.
How serious is the interaction between Brompheniramine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking both and choose one agent. Warn the patient against driving and alcohol use.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
