Drug interactions
Brompheniramine + Diphenoxylate
Severity: Moderate
Brompheniramine and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid, and with a sedating antihistamine it can cause additive drowsiness and CNS depression. Both also have anticholinergic effects that may worsen ileus or urinary retention.
What this interaction means in plain words
Brompheniramine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression via opioid agonism and H1 antagonism, with additive anticholinergic effects.
What to do
Monitor for sedation, constipation or abdominal distension, and urinary retention. Use caution in children and the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Brompheniramine with Diphenoxylate?
MediHelp rates the interaction as moderate. Brompheniramine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid, and with a sedating antihistamine it can cause additive drowsiness and CNS depression. Both also have anticholinergic effects that may worsen ileus or urinary retention.
How serious is the interaction between Brompheniramine and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, constipation or abdominal distension, and urinary retention. Use caution in children and the elderly.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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