Drug interactions
Brompheniramine + Dosulepin
Severity: Moderate
Brompheniramine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, so combined use increases drowsiness, cognitive impairment and effects such as dry mouth, constipation and urinary retention. Older patients are at higher risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Counsel on sedation and driving, and prefer a non-sedating antihistamine. Monitor for anticholinergic toxicity in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Brompheniramine with Dosulepin?
MediHelp rates the interaction as moderate. Brompheniramine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, so combined use increases drowsiness, cognitive impairment and effects such as dry mouth, constipation and urinary retention. Older patients are at higher risk of confusion and falls.
How serious is the interaction between Brompheniramine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and driving, and prefer a non-sedating antihistamine. Monitor for anticholinergic toxicity in older adults.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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