Drug interactions
Brompheniramine + Doxylamine
Severity: Moderate
Brompheniramine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two sedating first-generation antihistamines duplicate therapy and increase drowsiness, impaired alertness and anticholinergic adverse effects. Doxylamine is common in OTC sleep and cold products, so duplication is easy to miss.
What this interaction means in plain words
Brompheniramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Doxylamine belongs to Respiratory.
Why it happens
Additive central H1-receptor blockade and anticholinergic activity.
What to do
Avoid using both and review combination products for duplicate ingredients. Use a single agent at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Doxylamine
Frequently asked questions
Can I take Brompheniramine with Doxylamine?
MediHelp rates the interaction as moderate. Brompheniramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two sedating first-generation antihistamines duplicate therapy and increase drowsiness, impaired alertness and anticholinergic adverse effects. Doxylamine is common in OTC sleep and cold products, so duplication is easy to miss.
How serious is the interaction between Brompheniramine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both and review combination products for duplicate ingredients. Use a single agent at the lowest effective dose.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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