Drug interactions
Brompheniramine + Imipramine
Severity: Moderate
Brompheniramine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties. Combined with imipramine it can cause additive drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion.
What this interaction means in plain words
Brompheniramine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive antihistaminic, sedative and antimuscarinic effects.
What to do
Avoid driving and alcohol, and monitor for anticholinergic effects, especially in older adults. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Imipramine?
MediHelp rates the interaction as moderate. Brompheniramine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties. Combined with imipramine it can cause additive drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion.
How serious is the interaction between Brompheniramine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and monitor for anticholinergic effects, especially in older adults. Consider a non-sedating antihistamine instead.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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