Drug interactions
Brompheniramine + Isocarboxazid
Severity: Moderate
Brompheniramine and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of sedating antihistamines. This may cause marked drowsiness, dry mouth, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Brompheniramine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects, with possible MAOI-related slowing of antihistamine clearance.
What to do
Prefer a non-sedating antihistamine such as loratadine or fexofenadine. If brompheniramine is used, start at a low dose and monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Isocarboxazid?
MediHelp rates the interaction as moderate. Brompheniramine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of sedating antihistamines. This may cause marked drowsiness, dry mouth, urinary retention, confusion and tachycardia.
How serious is the interaction between Brompheniramine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine such as loratadine or fexofenadine. If brompheniramine is used, start at a low dose and monitor for sedation and anticholinergic effects.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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