Drug interactions
Brompheniramine + Lorazepam
Severity: Moderate
Brompheniramine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and with lorazepam it can intensify drowsiness and impair psychomotor performance. Elderly patients are at greater risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 receptor blockade and GABA-A potentiation.
What to do
Avoid or limit use of sedating antihistamines in older patients on lorazepam, or choose a non-sedating antihistamine. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Lorazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and with lorazepam it can intensify drowsiness and impair psychomotor performance. Elderly patients are at greater risk of confusion and falls.
How serious is the interaction between Brompheniramine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit use of sedating antihistamines in older patients on lorazepam, or choose a non-sedating antihistamine. Advise against driving and alcohol.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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