Drug interactions
Brompheniramine + Methadone
Severity: Moderate
Brompheniramine and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause excessive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression. The risk is greater in elderly patients and those with respiratory disease.
What this interaction means in plain words
Brompheniramine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from the opioid and the sedating first-generation antihistamine.
What to do
Counsel the patient about drowsiness and avoiding driving or hazardous tasks. Consider a non-sedating antihistamine and monitor sedation and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Methadone?
MediHelp rates the interaction as moderate. Brompheniramine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause excessive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression. The risk is greater in elderly patients and those with respiratory disease.
How serious is the interaction between Brompheniramine and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and avoiding driving or hazardous tasks. Consider a non-sedating antihistamine and monitor sedation and respiratory rate.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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