Drug interactions
Brompheniramine + Morphine
Severity: Moderate
Brompheniramine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines add to opioid-induced drowsiness and impair psychomotor performance, with additive anticholinergic effects such as constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1-receptor blockade and opioid receptor agonism.
What to do
Counsel patients on sedation and avoidance of driving, and consider a non-sedating antihistamine. Monitor older patients closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Morphine?
MediHelp rates the interaction as moderate. Brompheniramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines add to opioid-induced drowsiness and impair psychomotor performance, with additive anticholinergic effects such as constipation and urinary retention.
How serious is the interaction between Brompheniramine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on sedation and avoidance of driving, and consider a non-sedating antihistamine. Monitor older patients closely.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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