Drug interactions
Brompheniramine + Oxazepam
Severity: Moderate
Brompheniramine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine; with oxazepam it can cause additive drowsiness and impaired psychomotor performance. Older patients are at greater risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1-antagonism and GABA-A potentiation.
What to do
Warn patients about drowsiness, avoid alcohol, and consider a non-sedating antihistamine in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Oxazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine; with oxazepam it can cause additive drowsiness and impaired psychomotor performance. Older patients are at greater risk of confusion and falls.
How serious is the interaction between Brompheniramine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness, avoid alcohol, and consider a non-sedating antihistamine in older adults.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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