Drug interactions
Brompheniramine + Pitolisant
Severity: Moderate
Brompheniramine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant promotes wakefulness by increasing brain histamine signalling, and centrally acting H1 antagonists can block this effect. Efficacy of pitolisant may be reduced.
What this interaction means in plain words
Brompheniramine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Pitolisant belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: central H1 blockade opposes histamine-mediated wake promotion by pitolisant.
What to do
Avoid brompheniramine in patients on pitolisant and use an alternative such as a non-sedating peripherally selective antihistamine. Monitor for loss of wakefulness benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Brompheniramine with Pitolisant?
MediHelp rates the interaction as moderate. Brompheniramine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant promotes wakefulness by increasing brain histamine signalling, and centrally acting H1 antagonists can block this effect. Efficacy of pitolisant may be reduced.
How serious is the interaction between Brompheniramine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brompheniramine in patients on pitolisant and use an alternative such as a non-sedating peripherally selective antihistamine. Monitor for loss of wakefulness benefit.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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