Drug interactions
Brompheniramine + Primidone
Severity: Moderate
Brompheniramine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is an anticonvulsant metabolized partly to phenobarbital and causes sedation. With brompheniramine, drowsiness and impaired alertness may increase.
What this interaction means in plain words
Brompheniramine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Counsel about additive drowsiness and avoid alcohol and driving. Use a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Brompheniramine with Primidone?
MediHelp rates the interaction as moderate. Brompheniramine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is an anticonvulsant metabolized partly to phenobarbital and causes sedation. With brompheniramine, drowsiness and impaired alertness may increase.
How serious is the interaction between Brompheniramine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about additive drowsiness and avoid alcohol and driving. Use a non-sedating antihistamine if one is needed.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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