Drug interactions
Budesonide + Crizotinib
Severity: Moderate
Budesonide and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase budesonide exposure, raising the risk of systemic corticosteroid effects. The effect is most relevant with oral budesonide or prolonged therapy.
What this interaction means in plain words
Budesonide and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing budesonide first-pass and systemic metabolism.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia and adrenal suppression, and reduce the budesonide dose or duration if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Budesonide with Crizotinib?
MediHelp rates the interaction as moderate. Budesonide and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may increase budesonide exposure, raising the risk of systemic corticosteroid effects. The effect is most relevant with oral budesonide or prolonged therapy.
How serious is the interaction between Budesonide and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia and adrenal suppression, and reduce the budesonide dose or duration if they occur.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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