Drug interactions
Budesonide + Eslicarbazepine
Severity: Moderate
Budesonide and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower budesonide exposure, particularly with oral formulations that undergo extensive first-pass metabolism. This may reduce efficacy in conditions such as inflammatory bowel disease or eosinophilic esophagitis.
What this interaction means in plain words
Budesonide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases the metabolism of budesonide.
What to do
Monitor for loss of disease control and consider a higher budesonide dose or alternative therapy if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Budesonide with Eslicarbazepine?
MediHelp rates the interaction as moderate. Budesonide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower budesonide exposure, particularly with oral formulations that undergo extensive first-pass metabolism. This may reduce efficacy in conditions such as inflammatory bowel disease or eosinophilic esophagitis.
How serious is the interaction between Budesonide and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control and consider a higher budesonide dose or alternative therapy if response is inadequate.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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