Drug interactions
Bedaquiline + Eslicarbazepine
Severity: Major
Bedaquiline and Eslicarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline is metabolized by CYP3A4, and inducers lower its levels, risking reduced antimycobacterial activity and resistance. Labeling advises avoiding strong inducers; eslicarbazepine's effect is likely weaker.
What this interaction means in plain words
Bedaquiline and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, increasing bedaquiline metabolism.
What to do
Avoid the combination and use a non-inducing anticonvulsant; if unavoidable, monitor sputum culture conversion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
- Bosutinib + Eslicarbazepine Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Eslicarbazepine?
MediHelp rates the interaction as major. Bedaquiline and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline is metabolized by CYP3A4, and inducers lower its levels, risking reduced antimycobacterial activity and resistance. Labeling advises avoiding strong inducers; eslicarbazepine's effect is likely weaker.
How serious is the interaction between Bedaquiline and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing anticonvulsant; if unavoidable, monitor sputum culture conversion.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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