Drug interactions
Avapritinib + Eslicarbazepine
Severity: Major
Avapritinib and Eslicarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and strong or moderate inducers reduce exposure, potentially compromising efficacy. Labeling advises avoiding coadministration with strong and moderate inducers.
What this interaction means in plain words
Avapritinib and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, accelerating avapritinib clearance.
What to do
Avoid the combination and choose a non-inducing anticonvulsant; if unavoidable, monitor tumor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
- Bosutinib + Eslicarbazepine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Eslicarbazepine?
MediHelp rates the interaction as major. Avapritinib and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate, and strong or moderate inducers reduce exposure, potentially compromising efficacy. Labeling advises avoiding coadministration with strong and moderate inducers.
How serious is the interaction between Avapritinib and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing anticonvulsant; if unavoidable, monitor tumor response closely.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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