Drug interactions
Budesonide + Fosaprepitant
Severity: Minor
Budesonide and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor that can modestly raise budesonide exposure. With a single dose the effect is generally short-lived and of limited clinical significance.
What this interaction means in plain words
Budesonide and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant transiently inhibits CYP3A4, decreasing budesonide metabolism.
What to do
No routine adjustment is required for single-dose fosaprepitant; monitor for corticosteroid adverse effects if repeated cycles are given with oral budesonide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Fosaprepitant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Budesonide with Fosaprepitant?
MediHelp rates the interaction as minor. Budesonide and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor that can modestly raise budesonide exposure. With a single dose the effect is generally short-lived and of limited clinical significance.
How serious is the interaction between Budesonide and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required for single-dose fosaprepitant; monitor for corticosteroid adverse effects if repeated cycles are given with oral budesonide.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
