Drug interactions
Amobarbital + Fosaprepitant
Severity: Moderate
Amobarbital and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, and amobarbital may lower aprepitant exposure. This could reduce antiemetic protection during chemotherapy.
What this interaction means in plain words
Amobarbital and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 by amobarbital increases aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add rescue antiemetics if necessary; avoid chronic barbiturate use during aprepitant-based regimens if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
- Avanafil + Fosaprepitant Moderate
Frequently asked questions
Can I take Amobarbital with Fosaprepitant?
MediHelp rates the interaction as moderate. Amobarbital and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, and amobarbital may lower aprepitant exposure. This could reduce antiemetic protection during chemotherapy.
How serious is the interaction between Amobarbital and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add rescue antiemetics if necessary; avoid chronic barbiturate use during aprepitant-based regimens if feasible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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