Drug interactions
Amiodarone + Fosaprepitant
Severity: Moderate
Amiodarone and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may increase amiodarone concentrations after a single dose. The effect is generally short-lived but could add to bradycardia or QT risk.
What this interaction means in plain words
Amiodarone and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant, the active metabolite, inhibits CYP3A4 and reduces amiodarone metabolism.
What to do
Monitor heart rate and ECG around the time of fosaprepitant administration, particularly with repeated chemotherapy cycles. Reduce amiodarone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
- Avanafil + Fosaprepitant Moderate
Frequently asked questions
Can I take Amiodarone with Fosaprepitant?
MediHelp rates the interaction as moderate. Amiodarone and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may increase amiodarone concentrations after a single dose. The effect is generally short-lived but could add to bradycardia or QT risk.
How serious is the interaction between Amiodarone and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG around the time of fosaprepitant administration, particularly with repeated chemotherapy cycles. Reduce amiodarone dose if toxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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