Drug interactions
Flibanserin + Fosaprepitant
Severity: Contraindicated
Flibanserin and Fosaprepitant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor that can increase flibanserin exposure. This raises the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Fosaprepitant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flibanserin belongs to Genitourinary; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing flibanserin clearance.
What to do
Avoid the combination; withhold flibanserin around fosaprepitant administration or use an alternative antiemetic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Fosaprepitant
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
- Avanafil + Fosaprepitant Moderate
Frequently asked questions
Can I take Flibanserin with Fosaprepitant?
MediHelp rates the interaction as contraindicated. Flibanserin and Fosaprepitant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor that can increase flibanserin exposure. This raises the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Fosaprepitant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; withhold flibanserin around fosaprepitant administration or use an alternative antiemetic.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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