Drug interactions
Budesonide + Hydrochlorothiazide-lisinopril
Severity: Moderate
Budesonide and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically available budesonide can cause potassium loss, which adds to thiazide-induced hypokalemia. The risk is greater with oral or high-dose therapy and lower with inhaled or topical use.
What this interaction means in plain words
Budesonide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from mineralocorticoid effect of the corticosteroid and thiazide-induced kaliuresis.
What to do
Monitor serum potassium and magnesium during systemic budesonide treatment and replace as needed; lisinopril may partly offset the loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Budesonide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically available budesonide can cause potassium loss, which adds to thiazide-induced hypokalemia. The risk is greater with oral or high-dose therapy and lower with inhaled or topical use.
How serious is the interaction between Budesonide and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during systemic budesonide treatment and replace as needed; lisinopril may partly offset the loss.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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