Drug interactions
Budesonide + Ivacaftor
Severity: Minor
Budesonide and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and may slightly raise systemic budesonide exposure. Clinical consequences are unlikely to be significant.
What this interaction means in plain words
Budesonide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its M1 metabolite inhibit P-glycoprotein, modestly increasing budesonide absorption.
What to do
No routine adjustment needed; monitor for corticosteroid adverse effects with long-term oral use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Budesonide with Ivacaftor?
MediHelp rates the interaction as minor. Budesonide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-glycoprotein and may slightly raise systemic budesonide exposure. Clinical consequences are unlikely to be significant.
How serious is the interaction between Budesonide and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for corticosteroid adverse effects with long-term oral use.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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