Drug interactions
Enzalutamide + Ivacaftor
Severity: Major
Enzalutamide and Ivacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide can substantially reduce ivacaftor exposure and may cause loss of therapeutic effect in cystic fibrosis. Strong CYP3A inducers are not recommended with ivacaftor.
What this interaction means in plain words
Enzalutamide and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Enzalutamide induces CYP3A4, increasing ivacaftor clearance.
What to do
Avoid coadministration. Monitor lung function and symptoms if use is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Ivacaftor + Oxcarbazepine Major
Frequently asked questions
Can I take Enzalutamide with Ivacaftor?
MediHelp rates the interaction as major. Enzalutamide and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide can substantially reduce ivacaftor exposure and may cause loss of therapeutic effect in cystic fibrosis. Strong CYP3A inducers are not recommended with ivacaftor.
How serious is the interaction between Enzalutamide and Ivacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Monitor lung function and symptoms if use is unavoidable.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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