Drug interactions
clarithromycin + ivacaftor
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ ivacaftor levels → AE risk.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid or reduce dose per label.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with ivacaftor?
The interaction is rated: Major. ↑ ivacaftor levels → AE risk.
How serious is the interaction between clarithromycin and ivacaftor?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between clarithromycin and ivacaftor managed?
Avoid or reduce dose per label.
Why do clarithromycin and ivacaftor interact?
CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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