Drug interactions
Budesonide + Letermovir
Severity: Moderate
Budesonide and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A moderately and may raise budesonide exposure, increasing the potential for systemic corticosteroid effects, especially with oral budesonide.
What this interaction means in plain words
Budesonide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing budesonide metabolism.
What to do
Monitor for corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression, and use the lowest effective budesonide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Budesonide with Letermovir?
MediHelp rates the interaction as moderate. Budesonide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A moderately and may raise budesonide exposure, increasing the potential for systemic corticosteroid effects, especially with oral budesonide.
How serious is the interaction between Budesonide and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression, and use the lowest effective budesonide dose.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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