Drug interactions
Budesonide + Macimorelin
Severity: Moderate
Budesonide and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin is a diagnostic test for growth hormone deficiency, and glucocorticoids can alter growth hormone secretion. Rectal budesonide has lower systemic exposure, but the test result could still be affected in some patients.
What this interaction means in plain words
Budesonide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Macimorelin belongs to Endocrine.
Why it happens
Glucocorticoids may influence pituitary growth hormone release and alter the macimorelin test response; the exact effect is not well characterized.
What to do
Where feasible, allow a washout of budesonide before the macimorelin test and coordinate timing with the endocrinologist. Interpret results cautiously if the drug cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Macimorelin
Frequently asked questions
Can I take Budesonide with Macimorelin?
MediHelp rates the interaction as moderate. Budesonide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin is a diagnostic test for growth hormone deficiency, and glucocorticoids can alter growth hormone secretion. Rectal budesonide has lower systemic exposure, but the test result could still be affected in some patients.
How serious is the interaction between Budesonide and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, allow a washout of budesonide before the macimorelin test and coordinate timing with the endocrinologist. Interpret results cautiously if the drug cannot be stopped.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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