Drug interactions
Amisulpride + Macimorelin
Severity: Major
Amisulpride and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and macimorelin is used as a diagnostic agent whose labeling advises against QT-prolonging co-medication. Combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation through cardiac repolarization effects (hERG potassium channel blockade).
What to do
Avoid giving macimorelin to patients taking amisulpride; if the test is essential, consider a suitable washout of amisulpride or use an alternative diagnostic. Obtain an ECG and correct potassium and magnesium if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Amisulpride with Macimorelin?
MediHelp rates the interaction as major. Amisulpride and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and macimorelin is used as a diagnostic agent whose labeling advises against QT-prolonging co-medication. Combined use may raise the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking amisulpride; if the test is essential, consider a suitable washout of amisulpride or use an alternative diagnostic. Obtain an ECG and correct potassium and magnesium if the combination cannot be avoided.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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