Drug interactions
Amiodarone + Macimorelin
Severity: Major
Amiodarone and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin has a modest QT-prolonging effect and amiodarone is a strong QT-prolonging drug with a very long half-life. Combining them raises the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Amiodarone and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid macimorelin testing in patients taking amiodarone; use an alternative growth hormone stimulation test. Because amiodarone persists for months, washout is impractical.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Amiodarone with Macimorelin?
MediHelp rates the interaction as major. Amiodarone and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin has a modest QT-prolonging effect and amiodarone is a strong QT-prolonging drug with a very long half-life. Combining them raises the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Amiodarone and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing in patients taking amiodarone; use an alternative growth hormone stimulation test. Because amiodarone persists for months, washout is impractical.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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