Drug interactions
Asenapine + Macimorelin
Severity: Major
Asenapine and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin prolongs the QT interval and asenapine has a similar effect, so concurrent use can increase the risk of torsade de pointes. Macimorelin is used as a single-dose diagnostic test, so the exposure is short.
What this interaction means in plain words
Asenapine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid giving macimorelin to patients taking asenapine, and allow adequate washout of QT-prolonging drugs before testing. If the test is essential, consider an alternative diagnostic approach or ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Asenapine with Macimorelin?
MediHelp rates the interaction as major. Asenapine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin prolongs the QT interval and asenapine has a similar effect, so concurrent use can increase the risk of torsade de pointes. Macimorelin is used as a single-dose diagnostic test, so the exposure is short.
How serious is the interaction between Asenapine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking asenapine, and allow adequate washout of QT-prolonging drugs before testing. If the test is essential, consider an alternative diagnostic approach or ECG monitoring.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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