Drug interactions
Budesonide + Midazolam
Severity: Minor
Budesonide and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Budesonide is not a clinically significant CYP3A4 inducer at usual doses, so a meaningful reduction in midazolam exposure is not expected. The interaction is largely theoretical.
What this interaction means in plain words
Budesonide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 induction by corticosteroid; not established at budesonide doses.
What to do
No adjustment is required; titrate midazolam to clinical sedation effect as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Budesonide with Midazolam?
MediHelp rates the interaction as minor. Budesonide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Budesonide is not a clinically significant CYP3A4 inducer at usual doses, so a meaningful reduction in midazolam exposure is not expected. The interaction is largely theoretical.
How serious is the interaction between Budesonide and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; titrate midazolam to clinical sedation effect as usual.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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