Drug interactions
Budesonide + Simvastatin
Severity: Minor
Budesonide and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin has little ability to inhibit P-glycoprotein at clinical doses, so no meaningful change in budesonide exposure is expected. No clinically relevant interaction is established.
What this interaction means in plain words
Budesonide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Simvastatin belongs to Cardiovascular.
Why it happens
Theoretical weak P-glycoprotein interaction; not clinically established.
What to do
No action is required; continue both drugs with routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Budesonide with Simvastatin?
MediHelp rates the interaction as minor. Budesonide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin has little ability to inhibit P-glycoprotein at clinical doses, so no meaningful change in budesonide exposure is expected. No clinically relevant interaction is established.
How serious is the interaction between Budesonide and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required; continue both drugs with routine monitoring.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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