Drug interactions
Budesonide + Sirolimus
Severity: Minor
Budesonide and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Budesonide is not a significant CYP3A4 inducer, so a meaningful fall in sirolimus levels is unlikely. Systemic corticosteroid exposure may add to immunosuppression and infection risk.
What this interaction means in plain words
Budesonide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Sirolimus belongs to Miscellaneous.
Why it happens
No established pharmacokinetic mechanism; minor additive immunosuppression possible.
What to do
Continue routine sirolimus trough monitoring and watch for infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Budesonide with Sirolimus?
MediHelp rates the interaction as minor. Budesonide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Budesonide is not a significant CYP3A4 inducer, so a meaningful fall in sirolimus levels is unlikely. Systemic corticosteroid exposure may add to immunosuppression and infection risk.
How serious is the interaction between Budesonide and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine sirolimus trough monitoring and watch for infection.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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