Drug interactions
Budesonide + Tazemetostat
Severity: Moderate
Budesonide and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce budesonide exposure. This could diminish the efficacy of budesonide.
What this interaction means in plain words
Budesonide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases budesonide metabolism.
What to do
Monitor clinical response to budesonide and adjust the dose if disease control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Tazemetostat
Frequently asked questions
Can I take Budesonide with Tazemetostat?
MediHelp rates the interaction as moderate. Budesonide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce budesonide exposure. This could diminish the efficacy of budesonide.
How serious is the interaction between Budesonide and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to budesonide and adjust the dose if disease control worsens.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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