Drug interactions
Chloramphenicol + Tazemetostat
Severity: Major
Chloramphenicol and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may heighten dose-related adverse effects of tazemetostat.
What this interaction means in plain words
Chloramphenicol and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Tazemetostat belongs to Miscellaneous.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of tazemetostat.
What to do
Use an alternative antibiotic. If unavoidable, reduce the tazemetostat dose per labeling for CYP3A4 inhibitors and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Tazemetostat
Frequently asked questions
Can I take Chloramphenicol with Tazemetostat?
MediHelp rates the interaction as major. Chloramphenicol and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tazemetostat is metabolized by CYP3A4, so chloramphenicol may increase its exposure. This may heighten dose-related adverse effects of tazemetostat.
How serious is the interaction between Chloramphenicol and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic. If unavoidable, reduce the tazemetostat dose per labeling for CYP3A4 inhibitors and monitor for toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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