Drug interactions
Apalutamide + Tazemetostat
Severity: Major
Apalutamide and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce tazemetostat exposure, potentially decreasing antitumor efficacy in epithelioid sarcoma or follicular lymphoma.
What this interaction means in plain words
Apalutamide and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Strong CYP3A4 induction increases tazemetostat clearance.
What to do
Avoid strong CYP3A inducers with tazemetostat and use an alternative to apalutamide if feasible. Monitor tumor response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Apalutamide with Tazemetostat?
MediHelp rates the interaction as major. Apalutamide and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may reduce tazemetostat exposure, potentially decreasing antitumor efficacy in epithelioid sarcoma or follicular lymphoma.
How serious is the interaction between Apalutamide and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inducers with tazemetostat and use an alternative to apalutamide if feasible. Monitor tumor response if unavoidable.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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