Drug interactions
Amobarbital + Tazemetostat
Severity: Major
Amobarbital and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and can lower tazemetostat exposure, which may reduce antitumor efficacy. Tazemetostat is cleared mainly by CYP3A4, so loss of exposure is clinically relevant.
What this interaction means in plain words
Amobarbital and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolism of tazemetostat.
What to do
Avoid concurrent use and choose a non-inducing sedative or anticonvulsant where possible. If it cannot be avoided, monitor for loss of tazemetostat response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amobarbital with Tazemetostat?
MediHelp rates the interaction as major. Amobarbital and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital induces CYP3A4 and can lower tazemetostat exposure, which may reduce antitumor efficacy. Tazemetostat is cleared mainly by CYP3A4, so loss of exposure is clinically relevant.
How serious is the interaction between Amobarbital and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-inducing sedative or anticonvulsant where possible. If it cannot be avoided, monitor for loss of tazemetostat response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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