Drug interactions
Budesonide + Tecovirimat
Severity: Minor
Budesonide and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak inducer of CYP3A4 and may modestly lower systemic exposure to budesonide, which is extensively metabolized by this enzyme. The clinical effect is likely small, but local or systemic corticosteroid efficacy could be somewhat reduced.
What this interaction means in plain words
Budesonide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases budesonide first-pass and hepatic metabolism.
What to do
Monitor for loss of disease control with budesonide during tecovirimat therapy. Increase the budesonide dose only if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Budesonide with Tecovirimat?
MediHelp rates the interaction as minor. Budesonide and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak inducer of CYP3A4 and may modestly lower systemic exposure to budesonide, which is extensively metabolized by this enzyme. The clinical effect is likely small, but local or systemic corticosteroid efficacy could be somewhat reduced.
How serious is the interaction between Budesonide and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control with budesonide during tecovirimat therapy. Increase the budesonide dose only if symptoms worsen.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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