Drug interactions
Darunavir + Tecovirimat
Severity: Moderate
Darunavir and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat may modestly lower darunavir concentrations, with potential loss of antiviral effect. Boosted regimens are likely to mitigate this, and the clinical significance is uncertain.
What this interaction means in plain words
Darunavir and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly induces CYP3A, increasing darunavir clearance.
What to do
Monitor HIV viral load and adherence to the boosted regimen during and after the tecovirimat course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
- Maraviroc + Tecovirimat Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Tecovirimat?
MediHelp rates the interaction as moderate. Darunavir and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat may modestly lower darunavir concentrations, with potential loss of antiviral effect. Boosted regimens are likely to mitigate this, and the clinical significance is uncertain.
How serious is the interaction between Darunavir and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and adherence to the boosted regimen during and after the tecovirimat course.
What other medicines interact with Tecovirimat?
MediHelp also lists interactions of Tecovirimat with, for example, Bosentan, Cyclosporin, Ethinyl estradiol-drospirenone. The full list is on the Tecovirimat page.
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