Drug interactions
Cyclosporin + Tecovirimat
Severity: Moderate
Cyclosporin and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower cyclosporine concentrations. This could reduce immunosuppressive efficacy.
What this interaction means in plain words
Cyclosporin and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 increases cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations during and after tecovirimat therapy. Increase the dose if levels fall below target and reduce again after tecovirimat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
- Maraviroc + Tecovirimat Moderate
Frequently asked questions
Can I take Cyclosporin with Tecovirimat?
MediHelp rates the interaction as moderate. Cyclosporin and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat is a weak CYP3A4 inducer and may modestly lower cyclosporine concentrations. This could reduce immunosuppressive efficacy.
How serious is the interaction between Cyclosporin and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations during and after tecovirimat therapy. Increase the dose if levels fall below target and reduce again after tecovirimat is stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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