Drug interactions
Ethinyl estradiol-levonorgestrel + Tecovirimat
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower concentrations of ethinyl estradiol and levonorgestrel. The effect on contraceptive efficacy is likely small but possible.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction increases metabolic clearance of the contraceptive steroids.
What to do
Recommend an additional barrier method during the short tecovirimat course and for a few days after. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
- Maraviroc + Tecovirimat Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Tecovirimat?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat is a weak CYP3A4 inducer and may modestly lower concentrations of ethinyl estradiol and levonorgestrel. The effect on contraceptive efficacy is likely small but possible.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional barrier method during the short tecovirimat course and for a few days after. Monitor for breakthrough bleeding.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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