Drug interactions
Budesonide + Trastuzumab deruxtecan
Severity: Moderate
Budesonide and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair host defence, trastuzumab deruxtecan through myelosuppression (neutropenia) and budesonide through corticosteroid immunosuppression, particularly with systemic exposure. Together they may increase infection risk. The effect with inhaled or locally acting budesonide is likely small.
What this interaction means in plain words
Budesonide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression from corticosteroid effects and drug-induced neutropenia.
What to do
Monitor neutrophil counts and for signs of infection during treatment. Use the lowest effective budesonide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Budesonide with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Budesonide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair host defence, trastuzumab deruxtecan through myelosuppression (neutropenia) and budesonide through corticosteroid immunosuppression, particularly with systemic exposure. Together they may increase infection risk. The effect with inhaled or locally acting budesonide is likely small.
How serious is the interaction between Budesonide and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and for signs of infection during treatment. Use the lowest effective budesonide dose.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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