Drug interactions
Budesonide-formoterol + Degarelix
Severity: Moderate
Budesonide-formoterol and Degarelix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, as an androgen deprivation therapy, may prolong the QT interval, and formoterol can also prolong QTc, particularly at high doses or with hypokalemia. Combined use may increase the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Budesonide-formoterol and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Degarelix belongs to Endocrine.
Why it happens
Additive QT prolongation through different pharmacodynamic mechanisms.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before and during therapy. Avoid formoterol doses above the labeled maximum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Budesonide-formoterol with Degarelix?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, as an androgen deprivation therapy, may prolong the QT interval, and formoterol can also prolong QTc, particularly at high doses or with hypokalemia. Combined use may increase the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Budesonide-formoterol and Degarelix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before and during therapy. Avoid formoterol doses above the labeled maximum.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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