Drug interactions
Budesonide-formoterol + Givinostat
Severity: Moderate
Budesonide-formoterol and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and formoterol may add to this effect. The combination raises the risk of serious ventricular arrhythmias, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Budesonide-formoterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT prolongation.
What to do
Perform ECGs before starting and periodically during concomitant use. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Budesonide-formoterol with Givinostat?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and formoterol may add to this effect. The combination raises the risk of serious ventricular arrhythmias, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Budesonide-formoterol and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECGs before starting and periodically during concomitant use. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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