Drug interactions
Budesonide-formoterol + Glasdegib
Severity: Moderate
Budesonide-formoterol and Glasdegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and formoterol may contribute additively, especially with electrolyte disturbance. This increases arrhythmia risk, including torsades de pointes.
What this interaction means in plain words
Budesonide-formoterol and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Glasdegib belongs to Oncology.
Why it happens
Additive QTc prolongation, with formoterol also causing beta-adrenergic hypokalemia.
What to do
If both are needed, obtain a baseline ECG and electrolytes and repeat periodically, correcting potassium and magnesium. Consider alternatives in patients with congenital long QT or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Budesonide-formoterol with Glasdegib?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and formoterol may contribute additively, especially with electrolyte disturbance. This increases arrhythmia risk, including torsades de pointes.
How serious is the interaction between Budesonide-formoterol and Glasdegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, obtain a baseline ECG and electrolytes and repeat periodically, correcting potassium and magnesium. Consider alternatives in patients with congenital long QT or other risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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